Laser immunotherapy: initial results from a human breast cancer pilot trial

Tomas Hode; Maria C. Guerra; Gabriela L. Ferrel; John A. Lunn; Orn Adelsteinsson; Robert E. Nordquist; Wei R. Chen

doi:10.1117/12.839766

25 February 2010 Laser immunotherapy: initial results from a human breast cancer pilot trial

Tomas Hode, Maria C. Guerra, Gabriela L. Ferrel, John A. Lunn, Orn Adelsteinsson, Robert E. Nordquist, Wei R. Chen

Proceedings Volume 7565, Biophotonics and Immune Responses V; 756507 (2010) https://doi.org/10.1117/12.839766
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Laser Immunotherapy is an experimental treatment modality for late-stage, metastatic tumors, which targets solid primary and/or secondary tumors and utilizes an autologous vaccine-like approach to stimulate immune responses. Specifically, laser immunotherapy combines laser-induced in situ tumor devitalization with an immunoadjuvant for local immunostimulation. Here we report the initial results from a human breast cancer pilot trial with laser immunotherapy. Six stage III and IV cancer patients were treated, all of which were considered to be out of all other options, and preliminary data at the three-month examination are presented. The immediate goal of the trial was to determine the patient tolerance and the toxicity of the therapy, the optimal dose for the alteration of the course of the disease, and the reduction of the tumor burden. Each patient was individually evaluated for toxicity tolerance through physical exams and by appropriate supplemental and routine laboratory tests. Observable tumors in patients were followed with physical examination and radiological evaluations. Treatment efficacy was judged by the size and number of local and distant metastases before and after treatment.

Citation Download Citation

Tomas Hode, Maria C. Guerra, Gabriela L. Ferrel, John A. Lunn, Orn Adelsteinsson, Robert E. Nordquist, and Wei R. Chen "Laser immunotherapy: initial results from a human breast cancer pilot trial", Proc. SPIE 7565, Biophotonics and Immune Responses V, 756507 (25 February 2010); https://doi.org/10.1117/12.839766

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