LCVR-based polarimetry: calibration issues

James C. Gladish; Donald D. Duncan

doi:10.1117/12.842699

24 February 2010 LCVR-based polarimetry: calibration issues

James C. Gladish, Donald D. Duncan

Proceedings Volume 7566, Optics in Tissue Engineering and Regenerative Medicine IV; 756609 (2010) https://doi.org/10.1117/12.842699
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Changes in the structural organization of biological tissue can be indicative of disease. The ability to measure and associate changes in structural organization with disease-related cellular architecture has significant diagnostic value. Here we present a spectral imaging polarimeter to probe the local structural organization of tissue. The system is based on liquid crystal technology, and is comprised of two modules, a Stokes generator and a polarimeter. The Stokes generator uses a pair of Liquid Crystal Variable Retarders (LCVRs) to generate a set of Stokes vectors incident on a sample, while the polarimeter utilizes a separate pair of LCVRs to analyze the scattered Stokes vectors. Characterization of the system is in terms of a data reduction matrix that relates the polarimeter measurements to the incident Stokes vector. Calibration of the polarimeter (calculation of the elements of this data reduction matrix) is performed by presenting a series of known Stokes vectors to the device. The resulting over-determined system of equations is solved using the Singular Value Decomposition. We discuss the construction and calibration of the system.

Citation Download Citation

James C. Gladish and Donald D. Duncan "LCVR-based polarimetry: calibration issues", Proc. SPIE 7566, Optics in Tissue Engineering and Regenerative Medicine IV, 756609 (24 February 2010); https://doi.org/10.1117/12.842699

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