Challenge for spectroscopic tomography of biomembrane using imaging type two-dimensional Fourier spectroscopy

Wei Qi; Ichiro Ishimaru

doi:10.1117/12.841520

26 February 2010 Challenge for spectroscopic tomography of biomembrane using imaging type two-dimensional Fourier spectroscopy

Wei Qi, Ichiro Ishimaru

Author Affiliations +

Proceedings Volume 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics; 757207 (2010) https://doi.org/10.1117/12.841520
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We propose an image-producing Fourier spectroscopic technology that enables two-dimensional spectroscopic images to be obtained within the focusing plane alone. This technology incorporates auto-correlational phase-shift interferometry that uses only object light generated by the bright points that optically make up the object. We are currently involved in studies of non-invasive technologies used to measure blood components such as glucose and lipids, which are measured for use in daily living. Previous studies have investigated non-invasive technologies that measure blood glucose levels by utilizing near-infrared light that permeates the skin well. It has been confirmed that subtle changes in the concentration of a glucose solution, a sample used to measure the glucose level, can be measured by analyzing the spectroscopic characteristics of near-infrared light; however, when applied to a biomembrane, technology such as this is incapable of precisely measuring the glucose level because light diffusion within the skin disturbs the measurement. Our proposed technology enables two-dimensional spectroscopy to a limited depth below the skin covered by the measurement. Specifically, our technology concentrates only on the vascular territory near the skin surface, which is only minimally affected by light diffusion, as discussed previously; the spectroscopic characteristics of this territory are obtained and the glucose level can be measured with good sensitivity. In this paper we propose an image-producing Fourier spectroscopy method that is used as the measuring technology in producing a three-dimensional spectroscopic image.

Citation Download Citation

Wei Qi and Ichiro Ishimaru "Challenge for spectroscopic tomography of biomembrane using imaging type two-dimensional Fourier spectroscopy", Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 757207 (26 February 2010); https://doi.org/10.1117/12.841520

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Spectroscopy

Imaging spectroscopy

Fourier spectroscopy

Glucose

Skin

Blood

Quantum dots

Show All Keywords

Keywords/Phrases

Search In:

Publication Years