Consistent pivotal role of posterior cingulate cortex in the default mode network revealed by partial correlation analysis

Rui Li; Juan Li; Xiaoyan Miao; Li Yao; Xia Wu

doi:10.1117/12.844038

9 March 2010 Consistent pivotal role of posterior cingulate cortex in the default mode network revealed by partial correlation analysis

Rui Li, Juan Li, Xiaoyan Miao, Li Yao, Xia Wu

Author Affiliations +

Proceedings Volume 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging; 76260C (2010) https://doi.org/10.1117/12.844038
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Resting-state functional MRI (fMRI) studies have suggested the posterior cingulate cortex (PCC) plays a pivotal role in the default mode network (DMN), a set of co-activated brain regions characterizing the resting-state brain. Concerning this finding we propose the following questions in this study: Does PCC consistently play the equally crucial role in the DMN across different subjects, such as healthy young and healthy old subjects? Whether the fMRI scan environments or parameters would affect the results? To address these questions, we collected resting-state fMRI data on four groups of subjects: two healthy young groups scanned under 3-T and 1.5-T MRI systems respectively, and two healthy elderly groups both scanned under 3-T MRI system but with different scan parameters. Then group independent component analysis was used to isolate the DMN, and partial correlation analysis was employed to reveal the direct interactions between brain regions from the DMN. Finally, we measured the connectivity between brain regions based on the number of significantly interacted links to every region within this network. We found that PCC was the brain region consistently having the largest number of directly interacted regions in the four groups, suggesting the pivotal role of PCC in the DMN was stable and consistent across healthy subjects. The results also suggested the function of PCC would be more critical in healthy elderly subjects compared with healthy young subjects. And the factors of scan environments and parameters did not show any obvious impact on the above conclusions in this investigation.

Citation Download Citation

Rui Li, Juan Li, Xiaoyan Miao, Li Yao, and Xia Wu "Consistent pivotal role of posterior cingulate cortex in the default mode network revealed by partial correlation analysis", Proc. SPIE 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 76260C (9 March 2010); https://doi.org/10.1117/12.844038

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Functional magnetic resonance imaging

Independent component analysis

Magnetic resonance imaging

Brain mapping

Neuroimaging

Scanners

Show All Keywords

Keywords/Phrases

Search In:

Publication Years