Emerging fiber optic endomicroscopy technologies towards noninvasive real-time visualization of histology in situ

Jiefeng Xi; Yuying Zhang; Li Huo; Yongping Chen; Toufic Jabbour; Ming-Jun Li; Xingde Li

doi:10.1117/12.867758

8 September 2010 Emerging fiber optic endomicroscopy technologies towards noninvasive real-time visualization of histology in situ

Jiefeng Xi, Yuying Zhang, Li Huo, Yongping Chen, Toufic Jabbour, Ming-Jun Li, Xingde Li

Author Affiliations +

Proceedings Volume 7653, Fourth European Workshop on Optical Fibre Sensors; 765307 (2010) https://doi.org/10.1117/12.867758
Event: (EWOFS'10) Fourth European Workshop on Optical Fibre Sensors, 2010, Porto, Portugal

Abstract

This paper reviews our recent developments of ultrathin fiber-optic endomicroscopy technologies for transforming high-resolution noninvasive optical imaging techniques to in vivo and clinical applications such as early disease detection and guidance of interventions. Specifically we describe an all-fiber-optic scanning endomicroscopy technology, which miniaturizes a conventional bench-top scanning laser microscope down to a flexible fiber-optic probe of a small footprint (i.e. ~2-2.5 mm in diameter), capable of performing two-photon fluorescence and second harmonic generation microscopy in real time. This technology aims to enable realtime visualization of histology in situ without the need for tissue removal. We will also present a balloon OCT endoscopy technology which permits high-resolution 3D imaging of the entire esophagus for detection of neoplasia, guidance of biopsy and assessment of therapeutic outcome. In addition we will discuss the development of functional polymeric fluorescent nanocapsules, which use only FAD approved materials and potentially enable fast track clinical translation of optical molecular imaging and targeted therapy.

Citation Download Citation

Jiefeng Xi, Yuying Zhang, Li Huo, Yongping Chen, Toufic Jabbour, Ming-Jun Li, and Xingde Li "Emerging fiber optic endomicroscopy technologies towards noninvasive real-time visualization of histology in situ", Proc. SPIE 7653, Fourth European Workshop on Optical Fibre Sensors, 765307 (8 September 2010); https://doi.org/10.1117/12.867758

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KEYWORDS

Optical coherence tomography

Tissues

Esophagus

Endomicroscopy

Fiber optics

Luminescence

Cancer

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