Photodynamic therapy on bladder cancer cells: further studies on the performance of Coimbra sensitizers

Antonio M. d'A. Rocha Gonsalves; Arménio C. Serra; Marta Pineiro; M. Filomena Botelho

doi:10.1117/12.854608

17 May 2010 Photodynamic therapy on bladder cancer cells: further studies on the performance of Coimbra sensitizers

Antonio M. d'A. Rocha Gonsalves, Arménio C. Serra, Marta Pineiro, M. Filomena Botelho

Proceedings Volume 7715, Biophotonics: Photonic Solutions for Better Health Care II; 77151N (2010) https://doi.org/10.1117/12.854608
Event: SPIE Photonics Europe, 2010, Brussels, Belgium

Abstract

Following previous studies where we developed some high performance porphyrin derivatives for photodynamic therapy demonstrating their activity in different cell lines, we now extend our attention to CRL1472 bladder cancer line. In this work the phototoxicity of several diaryl and tetraarylporphyrins with different structures were evaluated with different incubation times. The phototoxicity observed was not directly related to the concentration of photosensitizer inside cells. Uptake studies demonstrate that the brominated derivative 2 which despite the most efficient photosensitizer presents a poor tendency to enter into cells.

Citation Download Citation

Antonio M. d'A. Rocha Gonsalves, Arménio C. Serra, Marta Pineiro, and M. Filomena Botelho "Photodynamic therapy on bladder cancer cells: further studies on the performance of Coimbra sensitizers", Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77151N (17 May 2010); https://doi.org/10.1117/12.854608

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