Ultra high resolution ultra high sensitive optical micro-angiography based on super continuum light source

Lin An; Jia Qin; Zhongwei Zhi; Ruikang Wang

doi:10.1117/12.875365

11 February 2011 Ultra high resolution ultra high sensitive optical micro-angiography based on super continuum light source

Lin An, Jia Qin, Zhongwei Zhi, Ruikang Wang

Author Affiliations +

Proceedings Volume 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV; 788915 (2011) https://doi.org/10.1117/12.875365
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this paper, we demonstrate for the first time utilizing a super continuum light source to achieve ultra high sensitive Optical Micro-Angiography (UHS-OMAG) system. The broad band light with central wavelength around 800nm, emitted from the super continuum light source, could provide a ~2μm coherence gate for the system. Based on a fast CMOS camera, we could successfully develop a high speed (~70 kHz line rate) Fourier Domain Optical coherence tomography system. Applying the ultra high sensitive OMAG algorithm onto the system, we could visualize blood vessel networks buried within the tissue bed in a high resolution and high sensitivity mode. The modality is performed on imaging the human finger nail fold and the mouse pinna to obtain both high resolution structure image and detailed blood perfusion map. The excellent performance shows a great potential of our system in future biological imaging application.

Citation Download Citation

Lin An, Jia Qin, Zhongwei Zhi, and Ruikang Wang "Ultra high resolution ultra high sensitive optical micro-angiography based on super continuum light source", Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 788915 (11 February 2011); https://doi.org/10.1117/12.875365

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available