Near-infrared pulsed light to guide prostate biopsy

J. Boutet; M. Debourdeau; A. Laidevant; L. Hervé; C. Allié; D. Vray; J.-M. Dinten

doi:10.1117/12.874631

16 February 2011 Near-infrared pulsed light to guide prostate biopsy

J. Boutet, M. Debourdeau, A. Laidevant, L. Hervé, C. Allié, D. Vray, J.-M. Dinten

Proceedings Volume 7895, Optical Biopsy IX; 78950N (2011) https://doi.org/10.1117/12.874631
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The protocol for prostate cancer diagnosis, currently based on ultrasound guided biopsy, is limited by a lack of relevance. To improve this protocol, a new approach was proposed combining optical and ultrasound measurements to guide biopsy specifically to the tumors. Adding an optical measurement modality into an already existing ultrasound probe is challenging as the overall size of the system should not exceed a given dimension so as to fit the operative environment. Moreover, examination should not take more than 15 min to avoid any complication. A combined ultrasound and optical endorectal probe was designed to comply with the constraints of the sterilization protocols, the examination duration and required compactness. Therefore a totally innovative pulsed laser source has been designed to meet compactness requirements while providing accurate time-resolved measurements. A dedicated multi-channel photon counting system was optimized to decrease the examination duration. A fast reconstruction method based on the analysis of the intensity and time of flight of the detected photons has been associated to provide 3D localization of fluorescent dots almost immediately after acquisition. The bi-modal probe was capable of withstanding the sterilization procedures. The performance of the compact laser source has been shown at the same level as that of a standard laboratory Titane:Sapphire laser. The dedicated photon counting solution was capable of acquiring optical data in less than one minute. To evaluate the overall performance of the system in dealing with a realistic background signal, measurements and reconstructions were conducted on prostate mimicking phantom and in vivo.

Citation Download Citation

J. Boutet, M. Debourdeau, A. Laidevant, L. Hervé, C. Allié, D. Vray, and J.-M. Dinten "Near-infrared pulsed light to guide prostate biopsy", Proc. SPIE 7895, Optical Biopsy IX, 78950N (16 February 2011); https://doi.org/10.1117/12.874631

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KEYWORDS

Prostate

Ultrasonography

Biopsy

Luminescence

Optical fibers

Fiber lasers

Tumors

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