Target detection and characterization using a hybrid handheld diffuse optical tomography and photoacoustic tomography system

Patrick D. Kumavor; Andres Aguirre; Chen Xu; John Gamelin; Yasaman Ardeshirpour; Behnoosh Tavakoli; Saeid Zanganeh; Umar S. Alqasemi; Quing Zhu

doi:10.1117/12.878913

1 March 2011 Target detection and characterization using a hybrid handheld diffuse optical tomography and photoacoustic tomography system

Patrick D. Kumavor, Andres Aguirre, Chen Xu, John Gamelin, Yasaman Ardeshirpour, Behnoosh Tavakoli, Saeid Zanganeh, Umar S. Alqasemi, Quing Zhu

Author Affiliations +

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 789614 (2011) https://doi.org/10.1117/12.878913
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A handheld photoacoustic tomography-guided diffuse optical tomography system for imaging deeply-seated targets in scattering media is presented. This hybrid imager consists of a probe with an ultrasound transducer in the center and straddled by two optical fibers for taking photoacoustic images. The diffuse optical tomography component comprises of 9 light-source fibers for delivering light to the imaged tissue, and 14 detector fibers for collecting the light. Single- and two-phantom targets of high and low optical contrasts were immersed in a scattering intralipid solution to depths of up to 3cm and imaged. The reconstructed absorption coefficients of the targets with guidance from photoacoustic tomography were compared to those obtained with a-priori depth-only information, and no a-priori information. The reconstructed absorption maps yielded as much as 2.6-fold improvement in the quantification accuracy compared to the cases with no guidance from photoacoustic tomography.

Citation Download Citation

Patrick D. Kumavor, Andres Aguirre, Chen Xu, John Gamelin, Yasaman Ardeshirpour, Behnoosh Tavakoli, Saeid Zanganeh, Umar S. Alqasemi, and Quing Zhu "Target detection and characterization using a hybrid handheld diffuse optical tomography and photoacoustic tomography system", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789614 (1 March 2011); https://doi.org/10.1117/12.878913

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