Non-invasive optical modulation of local vascular permeability

Myunghwan Choi; Chulhee Choi M.D.

doi:10.1117/12.873832

17 February 2011 Non-invasive optical modulation of local vascular permeability

Myunghwan Choi, Chulhee Choi M.D.

Proceedings Volume 7897, Optical Interactions with Tissue and Cells XXII; 78970A (2011) https://doi.org/10.1117/12.873832
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

For a systemically administered drug to act, it first needs to cross the vascular wall. This step represents a bottleneck for drug development, especially in the brain or retina, where tight junctions between endothelial cells form physiological barriers. Here, we demonstrate that femtosecond pulsed laser irradiation focused on the blood vessel wall induces transient permeabilization of plasma. Nonlinear absorption of the pulsed laser enabled the noninvasive modulation of vascular permeability with high spatial selectivity in three dimensions. By combining this method with systemic injection, we could locally deliver molecular probes in various tissues, such as brain cortex, meninges, ear, striated muscle, and bone. We suggest this method as a novel delivery tool for molecular probes or drugs.

Citation Download Citation

Myunghwan Choi and Chulhee Choi M.D. "Non-invasive optical modulation of local vascular permeability", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78970A (17 February 2011); https://doi.org/10.1117/12.873832

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