Detection of pre-charring optical behavior at a laser catheter-tip in blood: ex vivo and in vivo study

Mei Takahashi; Arisa Ito; Takuro Kajihara; Tsunenori Arai

doi:10.1117/12.874622

17 February 2011 Detection of pre-charring optical behavior at a laser catheter-tip in blood: ex vivo and in vivo study

Mei Takahashi, Arisa Ito, Takuro Kajihara, Tsunenori Arai

Proceedings Volume 7897, Optical Interactions with Tissue and Cells XXII; 78970U (2011) https://doi.org/10.1117/12.874622
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We studied a pre-charring optical behavior of blood at a laser catheter-tip during a red laser irradiation (663 nm, CW) with around 50 W/cm² in blood to prevent charring at the laser catheter-tip. The laser irradiated red-blood-cell shape changes were microscopically observed. A round formation, aggregation, and hemolysis were found until blood charring (ex vivo). A time-history of diffuse-reflected light power and transmitted light power from a thin blood layer which was irradiated by the red laser were measured with microscope optics to investigate the charring process. The diffusereflected light power decreased following a gentle peak before the charring. This decrease indicated the pre-charring behavior which might be induced by scattering and absorption changes due to red-blood-cell degenerations described above. Using the laser catheter located in porcine heart, we successfully detected the pre-charring behavior by a backscattering light power (in vivo). We demonstrated charring prevention availability with the laser power control (ex vivo). We think that the backscattering light power measurement and laser power control via the laser catheter might be useful to detect pre-charring behavior, and to prevent the charring for therapeutic laser irradiation in blood under catheterization such as arrhythmia treatment with photodynamic therapy.

Citation Download Citation

Mei Takahashi, Arisa Ito, Takuro Kajihara, and Tsunenori Arai "Detection of pre-charring optical behavior at a laser catheter-tip in blood: ex vivo and in vivo study", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78970U (17 February 2011); https://doi.org/10.1117/12.874622

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