Initial experiences in the photoacoustic detection of melanoma metastases in resected lymph nodes

D. Grootendorst; J. Jose; P. Van der Jagt; W. Van der Weg; K. Nagel; M. Wouters; H. Van Boven; T. G. Van Leeuwen; W. Steenbergen; T. Ruers; S. Manohar

doi:10.1117/12.875456

22 February 2011 Initial experiences in the photoacoustic detection of melanoma metastases in resected lymph nodes

D. Grootendorst, J. Jose, P. Van der Jagt, W. Van der Weg, K. Nagel, M. Wouters, H. Van Boven, T. G. Van Leeuwen, W. Steenbergen, T. Ruers, S. Manohar

Author Affiliations +

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78993J (2011) https://doi.org/10.1117/12.875456
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Accurate lymph node analysis is essential to determine the prognosis and treatment of patients suffering from melanoma. The initial results of a tomographic photoacoustic modality to detect melanoma metastases in resected lymph nodes are presented based on phantom models and a human lymph node. The results show melanoma metastases detection is feasible and the setup is capable of distinguishing absorbing structures down to 1 mm. In addition, the use of longer laser wavelengths could result in an image containing a higher contrast ratio. Future research shall be focused on using the melanin characteristics to improve contrast and detection possibilities.

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D. Grootendorst, J. Jose, P. Van der Jagt, W. Van der Weg, K. Nagel, M. Wouters, H. Van Boven, T. G. Van Leeuwen, W. Steenbergen, T. Ruers, and S. Manohar "Initial experiences in the photoacoustic detection of melanoma metastases in resected lymph nodes", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993J (22 February 2011); https://doi.org/10.1117/12.875456

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