Monitoring of HIFU thermal damage using integrated photoacoustic imaging and high intensity focused ultrasound technique

Huizhong Cui; Xinmai Yang

doi:10.1117/12.875505

22 February 2011 Monitoring of HIFU thermal damage using integrated photoacoustic imaging and high intensity focused ultrasound technique

Huizhong Cui, Xinmai Yang

Author Affiliations +

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78993L (2011) https://doi.org/10.1117/12.875505
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this study, we applied an integrated photoacoustic imaging (PAI) and high intensity focused ultrasound (HIFU) system to noninvasively monitor the thermal damage due to HIFU ablation in vivo. A single-element, spherically focused ultrasonic transducer, with a central frequency of 5MHz, was used to generate a HIFU area in soft tissue. Photoacoustic signals were detected by the same ultrasonic transducer before and after HIFU treatments using different wavelengths. The feasibility of combined contrast imaging and treatment of solid tumor in vivo by the integrated PAI and HIFU system was also studied. Gold nanorods were used to enhance PAI during the imaging of a CT26 tumor, which was subcutaneously inoculated on the hip of a BALB/c mouse. Subsequently, the CT26 tumor was ablated by HIFU with the guidance of photoacoustic images. Our results suggested that the tumor was clearly visible on photoacoustic images after the injection of gold nanorods and was ablated by HIFU. In conclusion, PAI may potentially be used for monitoring HIFU thermal lesions with possible diagnosis and treatment of solid tumors.

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Huizhong Cui and Xinmai Yang "Monitoring of HIFU thermal damage using integrated photoacoustic imaging and high intensity focused ultrasound technique", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993L (22 February 2011); https://doi.org/10.1117/12.875505

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KEYWORDS

Tumors

Transducers

Nanorods

Gold

In vivo imaging

Photoacoustic spectroscopy

Ultrasonography

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