Accelerated binding kinetics by surface acoustic waves (SAW) micromixing in surface plasmon resonance (SPR) system for biodetection

Alan Renaudin; Vincent Chabot; Etienne Grondin; Vincent Aimez; Paul G. Charette

doi:10.1117/12.876508

14 February 2011 Accelerated binding kinetics by surface acoustic waves (SAW) micromixing in surface plasmon resonance (SPR) system for biodetection

Alan Renaudin, Vincent Chabot, Etienne Grondin, Vincent Aimez, Paul G. Charette

Author Affiliations +

Proceedings Volume 7929, Microfluidics, BioMEMS, and Medical Microsystems IX; 79290M (2011) https://doi.org/10.1117/12.876508
Event: SPIE MOEMS-MEMS, 2011, San Francisco, California, United States

Abstract

A design incorporating surface plasmon resonance (SPR) biosensing and surface acoustic wave (SAW) active microfluidic mixing, integrated on a single LiNbO₃ piezoelectric substrate, is presented. Validation experiments show that SAW-mixing (microstreaming) results in accelerated binding kinetics (time-to-saturation) for a standard assay with appropriate SAW excitation parameters. Since both SPR sensors and SAW transducers can be fabricated simultaneously using low-cost microfabrication methods, the proposed design should contribute to improved lab-on-chip devices for detecting and identifying biomolecules of interest with greater accuracy and speed across multiple applications.

Citation Download Citation

Alan Renaudin, Vincent Chabot, Etienne Grondin, Vincent Aimez, and Paul G. Charette "Accelerated binding kinetics by surface acoustic waves (SAW) micromixing in surface plasmon resonance (SPR) system for biodetection", Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290M (14 February 2011); https://doi.org/10.1117/12.876508

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