Susceptibility quantification in MRI using modified conjugate gradient least square method

Luning Wang; Jason Langley; Qun Zhao

doi:10.1117/12.878374

16 March 2011 Susceptibility quantification in MRI using modified conjugate gradient least square method

Luning Wang, Jason Langley, Qun Zhao

Proceedings Volume 7961, Medical Imaging 2011: Physics of Medical Imaging; 79613T (2011) https://doi.org/10.1117/12.878374
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

MR susceptometry provides a new approach to enhance contrast in MR imaging and quantify substances such as iron, calcium, blood oxygenation in various organs for the clinical diagnosis of many diseases. Susceptibility is closely related to the magnetic field inhomogeneity in MRI, and calculation of susceptibility from the measured magnetic field is an ill-posed inverse problem. Conjugate gradient least square (CGLS) method with Tikhonov regularization is a powerful tool to solve the inverse problems. However, the estimated quantity in CGLS method is usually in one-dimensional (e.g., a column vector) while the most of MR data are in the form of three dimensions. In this work, the least square problem is modified to enable the calculation of susceptibility directly from three-dimensional MR phase maps, which has the benefit of reducing the size of associated matrices and usage of computer memories. Numerical simulations were used to find the proper regularization parameters and study the influence of different noise levels of the magnetic field on the regularization parameters. Experiments of superparamagnetic iron oxide phantom were also conducted. Both of the results demonstrate the validation and accuracy of this method.

Citation Download Citation

Luning Wang, Jason Langley, and Qun Zhao "Susceptibility quantification in MRI using modified conjugate gradient least square method", Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 79613T (16 March 2011); https://doi.org/10.1117/12.878374

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available