X-ray phase computed tomography for nanoparticulated imaging probes and therapeutics: preliminary feasibility study

Xiangyang Tang; Yi Yang; Shaojie Tang

doi:10.1117/12.877878

16 March 2011 X-ray phase computed tomography for nanoparticulated imaging probes and therapeutics: preliminary feasibility study

Xiangyang Tang, Yi Yang, Shaojie Tang

Author Affiliations +

Proceedings Volume 7961, Medical Imaging 2011: Physics of Medical Imaging; 79614Z (2011) https://doi.org/10.1117/12.877878
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

With the scientific progress in cancer biology, pharmacology and biomedical engineering, the nano-biotechnology based imaging probes and therapeutical agents (namely probes/agents) - a form of theranostics - are among the strategic solutions bearing the hope for the cure of cancer. The key feature distinguishing the nanoparticulated probes/agents from their conventional counterparts is their targeting capability. A large surface-to-volume ratio in nanoparticulated probes/agents enables the accommodation of multiple targeting, imaging and therapeutic components to cope with the intra- and inter-tumor heterogeneity. Most nanoparticulated probes/agents are synthesized with low atomic number materials and thus their x-ray attenuation are very similar to biological tissues. However, their microscopic structures are very different, which may result in significant differences in their refractive properties. Recently, the investigation in the x-ray grating-based differential phase contrast (DPC) CT has demonstrated its advantages in differentiating low-atomic materials over the conventional attenuation-based CT. We believe that a synergy of x-ray grating-based DPC CT and nanoparticulated imaging probes and therapeutic agents may play a significant role in extensive preclinical and clinical applications, or even become a modality for molecular imaging. Hence, we propose to image the refractive property of nanoparticulated imaging probes and therapeutical agents using x-ray grating-based DPC CT. In this work, we conduct a preliminary feasibility study with a focus to characterize the contrast-to-noise ratio (CNR) and contrast-detail behavior of the x-ray grating-based DPC CT. The obtained data may be instructive to the architecture design and performance optimization of the x-ray grating-based DPC CT for imaging biomarker-targeted imaging probes and therapeutic agents, and even informative to the translation of preclinical research in theranostics into clinical applications.

Citation Download Citation

Xiangyang Tang, Yi Yang, and Shaojie Tang "X-ray phase computed tomography for nanoparticulated imaging probes and therapeutics: preliminary feasibility study", Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 79614Z (16 March 2011); https://doi.org/10.1117/12.877878

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