Multi-modal optical diagnostic approach for non-invasive imaging of blood and lymphatic vascular networks in vivo

Vyacheslav Kalchenko; Yuri Kuznetsov; Igor Meglinski; Alon Harmelin

doi:10.1117/12.890506

21 March 2011 Multi-modal optical diagnostic approach for non-invasive imaging of blood and lymphatic vascular networks in vivo

Vyacheslav Kalchenko, Yuri Kuznetsov, Igor Meglinski, Alon Harmelin

Author Affiliations +

Proceedings Volume 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII; 799904 (2011) https://doi.org/10.1117/12.890506
Event: Saratov Fall Meeting 2010, 2010, Saratov, Russian Federation

Abstract

The use of multi-modal optical diagnostic approach has a great potential in medicine and biology allowing significantly expand the capabilities of vascular diagnostics. Multi-modal approach provides synchronic in vivo images of blood and lymph vessels. In current study the Dynamic Light Scattering approach has been used for rendering blood vessels structure and monitoring blood micro-flows in the mouse ear in vivo with the higher spatial resolution, whereas conventional Fluorescence Intravital Microscopy provides simultaneous image of lymphatic vessels. The results clearly demonstrate that combined application of Dynamic Light Scattering and conventional Fluorescence Intravital Microscopy approaches provides synchronic in vivo images of blood and lymph vessels as well as blood micro-flows with a high contrast and specificity.

Citation Download Citation

Vyacheslav Kalchenko, Yuri Kuznetsov, Igor Meglinski, and Alon Harmelin "Multi-modal optical diagnostic approach for non-invasive imaging of blood and lymphatic vascular networks in vivo", Proc. SPIE 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII, 799904 (21 March 2011); https://doi.org/10.1117/12.890506

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