Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography

Hrebesh M. Subhash; Hui Xie; Jeffrey W. Smith; Owen McCarty

doi:10.1117/12.889760

17 June 2011 Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, Owen McCarty

Author Affiliations +

Proceedings Volume 8091, Optical Coherence Tomography and Coherence Techniques V; 809108 (2011) https://doi.org/10.1117/12.889760
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.

Citation Download Citation

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, and Owen McCarty "Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography", Proc. SPIE 8091, Optical Coherence Tomography and Coherence Techniques V, 809108 (17 June 2011); https://doi.org/10.1117/12.889760

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Nanoparticles

Optical coherence tomography

Particles

Tissues

Near infrared

Polymers

Absorption

Show All Keywords

Keywords/Phrases

Search In:

Publication Years