Application of covariance images and PCA to study the stages of dysplasia in human cervical tissues

Jaidip Jagtap; Meghdoot Mozumder; Prashant Shukla; Kiran Pandey; Asha Agarwal; Asima Pradhan

doi:10.1117/12.898533

12 August 2011 Application of covariance images and PCA to study the stages of dysplasia in human cervical tissues

Jaidip Jagtap, Meghdoot Mozumder, Prashant Shukla, Kiran Pandey, Asha Agarwal, Asima Pradhan

Proceedings Volume 8173, Photonics 2010: Tenth International Conference on Fiber Optics and Photonics; 817305 (2011) https://doi.org/10.1117/12.898533
Event: International Conference on Fiber Optics and Photonics, 2010, Guwahati, India

Abstract

Mueller Matrix has the potential to extract vital information regarding subtle morphological changes that appear in human tissue in the early stages of cancer. In this report we have analyzed data of Muller Matrix imaging obtained from human cervical tissue. The depolarization power quantifies the increase in density of cells in epithelium layer during the progress of dysplasia. The early changes in dysplasia seen in the breakdown of ordered collagen fiber of the stromal region result in changes in birefringence property. The retardance parameter of Mueller Matrix decomposition displays these changes quantitatively. Analysis of retardance images performed on measurements obtained from the stromal region shows significant differences to discriminate dysplasia from normal tissue, where histopathology fails to diagnose. Further, the covariance map of depolarization power and their highest eigenvector from the epithelial layer are able to grade the two different stages of dysplastic conditions, grade I (GD1) and grade II (GD2) in human cervical tissue. This study can improve sensitivity of detection in clinics as a supplementary technique to histopathology.

Citation Download Citation

Jaidip Jagtap, Meghdoot Mozumder, Prashant Shukla, Kiran Pandey, Asha Agarwal, and Asima Pradhan "Application of covariance images and PCA to study the stages of dysplasia in human cervical tissues", Proc. SPIE 8173, Photonics 2010: Tenth International Conference on Fiber Optics and Photonics, 817305 (12 August 2011); https://doi.org/10.1117/12.898533

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KEYWORDS

Tissues

Principal component analysis

Matrices

Wave plates

Collagen

Birefringence

Polarization

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