Transcranial photoacoustic tomography of the monkey brain

Liming Nie; Chao Huang; Zijian Guo; Mark Anastasio; Lihong V. Wang

doi:10.1117/12.907060

23 February 2012 Transcranial photoacoustic tomography of the monkey brain

Liming Nie, Chao Huang, Zijian Guo, Mark Anastasio, Lihong V. Wang

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82230L (2012) https://doi.org/10.1117/12.907060
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

A photoacoustic tomography (PAT) system using a virtual point ultrasonic transducer was developed for transcranial imaging of monkey brains. The virtual point transducer provided a 10 times greater field-of-view (FOV) than finiteaperture unfocused transducers, which enables large primate imaging. The cerebral cortex of a monkey brain was accurately mapped transcranially, through up to two skulls ranging from 4 to 8 mm in thickness. The mass density and speed of sound distributions of the skull were estimated from adjunct X-ray CT image data and utilized with a timereversal algorithm to mitigate artifacts in the reconstructed image due to acoustic aberration. The oxygenation saturation (sO2) in blood phantoms through a monkey skull was also imaged and quantified, with results consistent with measurements by a gas analyzer. The oxygenation saturation (sO2) in blood phantoms through a monkey skull was also imaged and quantified, with results consistent with measurements by a gas analyzer. Our experimental results demonstrate that PAT can overcome the optical and ultrasound attenuation of a relatively thick skull, and the imaging aberration caused by skull can be corrected to a great extent.

Citation Download Citation

Liming Nie, Chao Huang, Zijian Guo, Mark Anastasio, and Lihong V. Wang "Transcranial photoacoustic tomography of the monkey brain", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230L (23 February 2012); https://doi.org/10.1117/12.907060

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available