Intravascular photoacoustic imaging of gold nanorod-labeled atherosclerotic plaques

Doug Yeager; Andrei Karpiouk; Bo Wang; James Amirian; Konstantin Sokolov; Richard Smalling; Stanislav Emelianov

doi:10.1117/12.907125

23 February 2012 Intravascular photoacoustic imaging of gold nanorod-labeled atherosclerotic plaques

Doug Yeager, Andrei Karpiouk, Bo Wang, James Amirian, Konstantin Sokolov, Richard Smalling, Stanislav Emelianov

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82231Q (2012) https://doi.org/10.1117/12.907125
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging has been previously established as a viable means for imaging atherosclerotic plaques using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of an atherosclerotic rabbit aorta following injection of gold nanorods (AuNR) with peak absorbance within the tissue optical window was performed. Ex-vivo imaging results revealed high photoacoustic signal from localized AuNR. Corresponding histological cross-sections and digital photographs of the artery lumen confirmed the presence of AuNR preferentially located at atherosclerotic regions and in agreement with IVPA signal. Furthermore, an integrated IVUS/IVPA imaging catheter was used to image the AuNR in the presence of luminal blood. The results suggest that AuNR allow for IVPA imaging of exogenously labeled atherosclerotic plaques with a comparatively low background signal and without the need for arterial flushing.

Citation Download Citation

Doug Yeager, Andrei Karpiouk, Bo Wang, James Amirian, Konstantin Sokolov, Richard Smalling, and Stanislav Emelianov "Intravascular photoacoustic imaging of gold nanorod-labeled atherosclerotic plaques", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82231Q (23 February 2012); https://doi.org/10.1117/12.907125

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