Measuring tissue blood flow using ultrasound modulated diffused light

A. Ron; N. Racheli; I. Breskin; Y. Metzger; Z. Silman; M. Kamar; A. Nini; R. Shechter; M. Balberg

doi:10.1117/12.906349

23 February 2012 Measuring tissue blood flow using ultrasound modulated diffused light

A. Ron, N. Racheli, I. Breskin, Y. Metzger, Z. Silman, M. Kamar, A. Nini, R. Shechter, M. Balberg

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82232J (2012) https://doi.org/10.1117/12.906349
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We demonstrate the ability of a novel device employing ultrasound modulation of near infrared light (referred as "Ultrasound tagged light" or UTL) to perform non-invasive monitoring of blood flow in the microvascular level in tissue. Monitoring microcirculatory blood flow is critical in clinical situations affecting flow to different organs, such as the brain or the limbs. . However, currently there are no non-invasive devices that measure microcirculatory blood flow in deep tissue continuously. Our prototype device (Ornim Medical, Israel) was used to monitor tissue blood flow on anesthetized swine during controlled manipulations of increased and decreased blood flow. Measurements were done on the calf muscle and forehead of the animal and compared with Laser Doppler (LD). ROC analysis of the sensitivity and specificity for detecting an increase in blood flow on the calf muscle, demonstrated AUC = 0.951 for 23 systemic manipulations of cardiac output by Epinephrine injection, which is comparable to AUC = 0.943 using laser Doppler. Some examples of cerebral blood flow monitoring are presented, along with their individual ROC curves. UTL flowmetry is shown to be effective in detecting changes in cerebral and muscle blood flow in swine, and has merit in clinical applications.

Citation Download Citation

A. Ron, N. Racheli, I. Breskin, Y. Metzger, Z. Silman, M. Kamar, A. Nini, R. Shechter, and M. Balberg "Measuring tissue blood flow using ultrasound modulated diffused light", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82232J (23 February 2012); https://doi.org/10.1117/12.906349

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available