Intravital confocal Raman microscopy with multiplexed SERS contrast agents

Patrick Z. McVeigh; Brian C. Wilson

doi:10.1117/12.907048

6 February 2012 Intravital confocal Raman microscopy with multiplexed SERS contrast agents

Patrick Z. McVeigh, Brian C. Wilson

Proceedings Volume 8234, Plasmonics in Biology and Medicine IX; 82340D (2012) https://doi.org/10.1117/12.907048
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Intravital microscopy has been demonstrated to be a powerful technique for studying the delivery of contrast or therapeutic agents to tumours growing in a realistic 3D environment at high resolution. Surface enhanced Raman scattering (SERS)-active nanoparticle contrast agents provide the ability to improve in-vivo detection of tumour tissue through multiplex detection of their uniquely bright spectral lines. However, most work to date has been carried out in-vitro or in ex-vivo tissues. Here we present the results from confocal Raman microscopy in a dorsal skinfold window chamber in mice using SERS-active gold nanoparticle contrast agents directed towards an overexpressed tumour receptor tyrosine kinase.

Citation Download Citation

Patrick Z. McVeigh and Brian C. Wilson "Intravital confocal Raman microscopy with multiplexed SERS contrast agents", Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340D (6 February 2012); https://doi.org/10.1117/12.907048

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