Ultrasensitive system for the real-time detection of H2O2 based on strong coupling in a bioplasmonic system

S. Dutta-Gupta; G. Suarez; Ch. Santschi; L. Juillerat-Jeanneret; O. J. F. Martin

doi:10.1117/12.910292

6 February 2012 Ultrasensitive system for the real-time detection of H₂O₂ based on strong coupling in a bioplasmonic system

S. Dutta-Gupta, G. Suarez, Ch. Santschi, L. Juillerat-Jeanneret, O. J. F. Martin

Author Affiliations +

Proceedings Volume 8234, Plasmonics in Biology and Medicine IX; 82340K (2012) https://doi.org/10.1117/12.910292
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We theoretically investigate the dependence of the different parameters of an optical biosensor for the detection of Hydrogen peroxide (H₂O₂) based on absorption enhancement of Cytochrome c molecules near gold nanoparticles. H₂O₂ is a major reactive oxygen species which is involved in signaling pathways and oxidative stress in cells. We use the Green's function approach as well as confirm the corresponding simulation results using the surface integral formulation. Further we show that this technique can be applied for detection of other small molecules, like oxygen and carbon monoxide.

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S. Dutta-Gupta, G. Suarez, Ch. Santschi, L. Juillerat-Jeanneret, and O. J. F. Martin "Ultrasensitive system for the real-time detection of H₂O₂ based on strong coupling in a bioplasmonic system", Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340K (6 February 2012); https://doi.org/10.1117/12.910292

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