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28 February 2012 Creation of an ensemble of simulated cardiac cases and a human observer study: tools for the development of numerical observers for SPECT myocardial perfusion imaging
J. Michael O'Connor, P. Hendrik Pretorius, Howard C. Gifford, Robert Licho, Samuel Joffe, Matthew McGuiness, Shannon Mehurg, Michael Zacharias, Jovan G. Brankov
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Proceedings Volume 8318, Medical Imaging 2012: Image Perception, Observer Performance, and Technology Assessment; 83180R (2012) https://doi.org/10.1117/12.911502
Event: SPIE Medical Imaging, 2012, San Diego, California, United States
Abstract
Our previous Single Photon Emission Computed Tomography (SPECT) myocardial perfusion imaging (MPI) research explored the utility of numerical observers. We recently created two hundred and eighty simulated SPECT cardiac cases using Dynamic MCAT (DMCAT) and SIMIND Monte Carlo tools. All simulated cases were then processed with two reconstruction methods: iterative ordered subset expectation maximization (OSEM) and filtered back-projection (FBP). Observer study sets were assembled for both OSEM and FBP methods. Five physicians performed an observer study on one hundred and seventy-nine images from the simulated cases. The observer task was to indicate detection of any myocardial perfusion defect using the American Society of Nuclear Cardiology (ASNC) 17-segment cardiac model and the ASNC five-scale rating guidelines. Human observer Receiver Operating Characteristic (ROC) studies established the guidelines for the subsequent evaluation of numerical model observer (NO) performance. Several NOs were formulated and their performance was compared with the human observer performance. One type of NO was based on evaluation of a cardiac polar map that had been pre-processed using a gradient-magnitude watershed segmentation algorithm. The second type of NO was also based on analysis of a cardiac polar map but with use of a priori calculated average image derived from an ensemble of normal cases.
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J. Michael O'Connor, P. Hendrik Pretorius, Howard C. Gifford, Robert Licho, Samuel Joffe, Matthew McGuiness, Shannon Mehurg, Michael Zacharias, and Jovan G. Brankov "Creation of an ensemble of simulated cardiac cases and a human observer study: tools for the development of numerical observers for SPECT myocardial perfusion imaging", Proc. SPIE 8318, Medical Imaging 2012: Image Perception, Observer Performance, and Technology Assessment, 83180R (28 February 2012); https://doi.org/10.1117/12.911502
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KEYWORDS
Monte Carlo methods
Single photon emission computed tomography
Image segmentation
Arteries
NOx
Computer simulations
Heart
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