Simultaneous EEG and diffuse optical imaging of seizure-related hemodynamic activity in the newborn infant brain

Jeremy C. Hebden; Robert J. Cooper; Adam Gibson; Nick Everdell; Topun Austin

doi:10.1117/12.922990

8 May 2012 Simultaneous EEG and diffuse optical imaging of seizure-related hemodynamic activity in the newborn infant brain

Jeremy C. Hebden, Robert J. Cooper, Adam Gibson, Nick Everdell, Topun Austin

Author Affiliations +

Proceedings Volume 8427, Biophotonics: Photonic Solutions for Better Health Care III; 84271N (2012) https://doi.org/10.1117/12.922990
Event: SPIE Photonics Europe, 2012, Brussels, Belgium

Abstract

An optical imaging system has been developed which uses measurements of diffusely reflected near-infrared light to produce maps of changes in blood flow and oxygenation occurring within the cerebral cortex. Optical sources and detectors are coupled to the head via an array of optical fibers, on a probe held in contact with the scalp, and data is collected at a rate of 10 Hz. A clinical electroencephalography (EEG) system has been integrated with the optical system to enable simultaneous observation of electrical and hemodynamic activity in the cortex of neurologically compromised newborn infants diagnosed with seizures. Studies have made a potentially critically important discovery of previously unknown transient hemodynamic events in infants treated with anticonvulsant medication. We observed repeated episodes of small increases in cortical oxyhemoglobin concentration followed by a profound decrease in 3 of 4 infants studied, each with cerebral injury who presented with neonatal seizures. This was not accompanied by clinical or EEG seizure activity and was not present in nineteen matched controls. The underlying cause of these changes is currently unknown. We tentatively suggest that our results may be associated with a phenomenon known as cortical spreading depolarization, not previously observed in the infant brain.

Citation Download Citation

Jeremy C. Hebden, Robert J. Cooper, Adam Gibson, Nick Everdell, and Topun Austin "Simultaneous EEG and diffuse optical imaging of seizure-related hemodynamic activity in the newborn infant brain", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84271N (8 May 2012); https://doi.org/10.1117/12.922990

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