Development of drug delivery systems based on nanostructured porous silicon loaded with the anti-tumoral drug emodin adsorbed on silver nanoparticles

Margarita Hernández; Gonzalo Recio; Paz Sevilla; Vicente Torres-Costa; José V. García-Ramos; Concepción Domingo; Raúl J. J. Martín-Palma

doi:10.1117/12.931117

10 October 2012 Development of drug delivery systems based on nanostructured porous silicon loaded with the anti-tumoral drug emodin adsorbed on silver nanoparticles

Margarita Hernández, Gonzalo Recio, Paz Sevilla, Vicente Torres-Costa, José V. García-Ramos, Concepción Domingo, Raúl J. J. Martín-Palma

Author Affiliations +

Proceedings Volume 8465, Nanostructured Thin Films V; 846509 (2012) https://doi.org/10.1117/12.931117
Event: SPIE NanoScience + Engineering, 2012, San Diego, California, United States

Abstract

A study of the fluorescence and Raman spectra of a new and complex drug delivery system formed by emodin adsorbed on silver nanoparticles embedded into a matrix of porous silicon is here reported. Several experimental methods of inclusion of the drug-silver set inside the pores, without previous functionalization of porous silicon, have been tested in order to optimize the conditions for the fluorescence detection of emodin. In this sense, we have also added bovine serum albumin to the system, finding that the presence of the protein enhances the fluores-cence signal from emodin.

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Margarita Hernández, Gonzalo Recio, Paz Sevilla, Vicente Torres-Costa, José V. García-Ramos, Concepción Domingo, and Raúl J. J. Martín-Palma "Development of drug delivery systems based on nanostructured porous silicon loaded with the anti-tumoral drug emodin adsorbed on silver nanoparticles", Proc. SPIE 8465, Nanostructured Thin Films V, 846509 (10 October 2012); https://doi.org/10.1117/12.931117

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