Size control of ferrimagnetic iron oxide nanocubes to achieve optimum static dephasing regime r[sub]2[/sub] relaxivity for in vivo MRI

Youjin Lee; Nohyun Lee; Mihyun Park; Seung Hong Choi; Taeghwan Hyeon

doi:10.1117/12.999330

24 October 2012 Size control of ferrimagnetic iron oxide nanocubes to achieve optimum static dephasing regime r₂ relaxivity for in vivo MRI

Youjin Lee, Nohyun Lee, Mihyun Park, Seung Hong Choi, Taeghwan Hyeon

Author Affiliations +

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85482X (2012) https://doi.org/10.1117/12.999330
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

Ferrimagnetic nanoparticles have been limited in in vivo application because nanoparticles aggregate due to its remanent magnetization. Uniform-sized ferromagnetic iron oxide nanocubes with similar value of bulk saturated magnetization were synthesized. Control of nanocubes’ size minimized their remanence. PEG-phospholipid encapsulation enabled spacing to prevent the aggregation. As a result, water-dispersed single core ferrimagnetic iron oxide nanocubes were successfully prepared and their r₂ relaxivity was 761 s^-1mM^-1. It was very close to theoretical calculated value 800 s^-1mM^-1 in static dephasing regime. in vivo MR images were obtained after intravenous injection of 22 nm nanoparticles to a mouse. The MR signal of tumor site changed significantly. In this research, synthesized ferrimagnetic iron oxide nanocubes showed a superior T2 contrast effect and it would be able to improve the quality of early diagnosis and detection of tumor.

Citation Download Citation

Youjin Lee, Nohyun Lee, Mihyun Park, Seung Hong Choi, and Taeghwan Hyeon "Size control of ferrimagnetic iron oxide nanocubes to achieve optimum static dephasing regime r₂ relaxivity for in vivo MRI", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482X (24 October 2012); https://doi.org/10.1117/12.999330

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