Monitoring of human brain functions in risk decision-making task by diffuse optical tomography using voxel-wise general linear model

Zi-Jing Lin; Lin Li; Marry Cazzell; Hanli Liu

doi:10.1117/12.2005538

8 March 2013 Monitoring of human brain functions in risk decision-making task by diffuse optical tomography using voxel-wise general linear model

Zi-Jing Lin, Lin Li, Marry Cazzell, Hanli Liu

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 856555 (2013) https://doi.org/10.1117/12.2005538
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Functional near-infrared spectroscopy (fNIRS) is a non-invasive imaging technique which measures the hemodynamic changes that reflect the brain activity. Diffuse optical tomography (DOT), a variant of fNIRS with multi-channel NIRS measurements, has demonstrated capability of three dimensional (3D) reconstructions of hemodynamic changes due to the brain activity. Conventional method of DOT image analysis to define the brain activation is based upon the paired t-test between two different states, such as resting-state versus task-state. However, it has limitation because the selection of activation and post-activation period is relatively subjective. General linear model (GLM) based analysis can overcome this limitation. In this study, we combine the 3D DOT image reconstruction with GLM-based analysis (i.e., voxel-wise GLM analysis) to investigate the brain activity that is associated with the risk-decision making process. Risk decision-making is an important cognitive process and thus is an essential topic in the field of neuroscience. The balloon analogue risk task (BART) is a valid experimental model and has been commonly used in behavioral measures to assess human risk taking action and tendency while facing risks. We have utilized the BART paradigm with a blocked design to investigate brain activations in the prefrontal and frontal cortical areas during decision-making. Voxel-wise GLM analysis was performed on 18human participants (10 males and 8females).In this work, we wish to demonstrate the feasibility of using voxel-wise GLM analysis to image and study cognitive functions in response to risk decision making by DOT. Results have shown significant changes in the dorsal lateral prefrontal cortex (DLPFC) during the active choice mode and a different hemodynamic pattern between genders, which are in good agreements with published literatures in functional magnetic resonance imaging (fMRI) and fNIRS studies.

Citation Download Citation

Zi-Jing Lin, Lin Li, Marry Cazzell, and Hanli Liu "Monitoring of human brain functions in risk decision-making task by diffuse optical tomography using voxel-wise general linear model", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856555 (8 March 2013); https://doi.org/10.1117/12.2005538

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available