Video-rate photoacoustic microscopy of micro-vasculatures

Lidai Wang; Konstantin Maslov; Wenxin Xing; Alejandro Garcia-Uribe; Lihong V. Wang

doi:10.1117/12.2004714

4 March 2013 Video-rate photoacoustic microscopy of micro-vasculatures

Lidai Wang, Konstantin Maslov, Wenxin Xing, Alejandro Garcia-Uribe, Lihong V. Wang

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85811T (2013) https://doi.org/10.1117/12.2004714
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We report the development of photoacoustic microscopy capable of video-rate high-resolution in-vivo imaging in deep tissue. A lightweight photoacoustic probe is made of a single-element broadband ultrasound transducer, a compact photoacoustic beam combiner, and a bright-field light delivery system. Focused broadband ultrasound detection provides a 44-μm lateral resolution and a 28-μm axial resolution. A multimode optical fiber is used to deliver laser pulses. The bright-field light delivery system can effectively improve the illumination efficiency. The photoacoustic probe weighs less than 40 grams and is mounted on a voice-coil scanner to acquire 40 cross-sectional images per second over several-mm range. The fast speed can effectively improve imaging throughput, reduce motion artifacts, and enable the visualization of highly dynamic biomedical processes. High-resolution micro-vascular imaging is successfully demonstrated.

Citation Download Citation

Lidai Wang, Konstantin Maslov, Wenxin Xing, Alejandro Garcia-Uribe, and Lihong V. Wang "Video-rate photoacoustic microscopy of micro-vasculatures ", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85811T (4 March 2013); https://doi.org/10.1117/12.2004714

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Ultrasonography

Imaging systems

In vivo imaging

Photoacoustic spectroscopy

Pulsed laser operation

Tissue optics

Photoacoustic microscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years