Using immunoadjuvant agent glycated chitosan to enhance anti-cancer stem like cell immunity induced by HIFU

Y.-L. Chen; W.-R. Chen; R.-S. Liu; F.-Y. Yang; C.-Y. Wang; Y.-J. Lee

doi:10.1117/12.2002722

21 February 2013 Using immunoadjuvant agent glycated chitosan to enhance anti-cancer stem like cell immunity induced by HIFU

Y.-L. Chen, W.-R. Chen, R.-S. Liu, F.-Y. Yang, C.-Y. Wang, Y.-J. Lee

Author Affiliations +

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820R (2013) https://doi.org/10.1117/12.2002722
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Thermal therapy is based on the observation that tumor cells are sensitive to increased temperature, which is important for tumor control. In this study, the high intensity focused ultrasound (HIFU) system was used to simulate thermal therapy on breast cancer control in the small animal model. Additionally, the immunoadjuvant agent, so called glycated chitosan (GC), was used to enhance the immunological effects on tumor control. The bioluminescent imaging showed that tumor metastasis was apparently suppressed by a combined treatment using HIFU and GC, but not in HIFU or GC alone. Using immunohistochemical (IHC) staining, lung metastasis of 4T1-3R tumor cells further agree the observations obtained from non-invasive in vivo imaging. We also found that plasma collected from mice treated with combined HIFU and GC could significantly suppress the viability of cultured 4T1 cells compared to untreated or single treated group. In summary, these results suggest that the HIFU therapy combined with GC can enhance the tumor immunogenicity and tumor control.

Citation Download Citation

Y.-L. Chen, W.-R. Chen, R.-S. Liu, F.-Y. Yang, C.-Y. Wang, and Y.-J. Lee "Using immunoadjuvant agent glycated chitosan to enhance anti-cancer stem like cell immunity induced by HIFU", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820R (21 February 2013); https://doi.org/10.1117/12.2002722

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available