Assessment laser phototherapy on bone defects grafted or not with biphasic synthetic micro-granular HA + β-Tricalcium phosphate: histological study in an animal model

Luiz Guilherme P. Soares; Aparecida M. C. Marques; Jouber Mateus S. Aciole; Renan Trindade; Jean N. Santos; Antônio Luiz Barbosa Pinheiro

doi:10.1117/12.2036872

18 February 2014 Assessment laser phototherapy on bone defects grafted or not with biphasic synthetic micro-granular HA + β-tricalcium phosphate: histological study in an animal model

Luiz Guilherme P. Soares, Aparecida M. C. Marques, Jouber Mateus S. Aciole, Renan Trindade, Jean N. Santos, Antônio Luiz Barbosa Pinheiro

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Proceedings Volume 8932, Mechanisms for Low-Light Therapy IX; 893211 (2014) https://doi.org/10.1117/12.2036872
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Beside of biomaterials, Laser phototherapy has shown positive results as auxiliary therapy on bone repair. The aim of this study was to evaluate, through histological analysis, the influence of Laser phototherapy in the process of repair of bone defects grafted or not with Hydroxyapatite. Forty rats were divided into 4 groups each subdivided into 2 subgroups according to the time of sacrifice. Surgical bone defects were made on femur of each animal with a trephine drill. On animals of group Clot the defect was filled only by blood, on group Laser the defect filled with the clot and further irradiated. In group Biomaterial the defect was filled with HA + β-TCP graft. In group Laser + Biomaterial, the defect was filled with biomaterial and further irradiated. The irradiation protocols were performed every 48 hours during for 15 days. Animal death occurred after 15 and 30 days. The specimens were routinely processed and evaluated by light microscopy. Qualitative analysis showed that group Laser + Biomaterial was in a more advanced stage of repair at the end of the experimental time. It was concluded that the Laser irradiation improved the repair of bone defects grafted or not.

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Luiz Guilherme P. Soares, Aparecida M. C. Marques, Jouber Mateus S. Aciole, Renan Trindade, Jean N. Santos, and Antônio Luiz Barbosa Pinheiro "Assessment laser phototherapy on bone defects grafted or not with biphasic synthetic micro-granular HA + β-tricalcium phosphate: histological study in an animal model", Proc. SPIE 8932, Mechanisms for Low-Light Therapy IX, 893211 (18 February 2014); https://doi.org/10.1117/12.2036872

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