Photoacoustic correlation spectroscopy for calibration-free absolute quantification of particle concentration

Yong Zhou; Junjie Yao; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/12.2036635

3 March 2014 Photoacoustic correlation spectroscopy for calibration-free absolute quantification of particle concentration

Yong Zhou, Junjie Yao, Konstantin I. Maslov, Lihong V. Wang

Author Affiliations +

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 89431W (2014) https://doi.org/10.1117/12.2036635
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Currently, laser fluence calibration is typically required for quantitative measurement of particle concentration in photoacoustic microscopy. In this paper, we present another quantitative approach to measure absolute absorber concentrations by photoacoustic correlation spectroscopy. The proposed method is based on the fact that the Brownian motion induces particle count fluctuation in the detection volume. We first derived a theoretical model for photoacoustic signals and then applied our method to quantitative measurement of different concentrations of various particles. The experimental results agreed well with the predictions from the theoretical model, suggesting that our method can be used for absolute particle concentrations measurement.

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Yong Zhou, Junjie Yao, Konstantin I. Maslov, and Lihong V. Wang "Photoacoustic correlation spectroscopy for calibration-free absolute quantification of particle concentration", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89431W (3 March 2014); https://doi.org/10.1117/12.2036635

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KEYWORDS

Particles

Signal to noise ratio

Photoacoustic spectroscopy

Photon counting

Calibration

Tissue optics

Absorption

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