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Modern optical microscopy has resolution and diffraction limitations. But noninvasive functional photoacoustic computed tomography has overcome this limit, offering deep penetration with optical contrast and ultrasonic resolution of 1 cm depth or more -- up to 7 cm of penetration in some cases, such as evaluating sentinel lymph nodes for breast cancer staging. This opens up applications in whole body imaging, brain function, oxygen saturation, label-free cell analysis, and noninvasive cancer biopsies. View presentation video on SPIE’s Digital Library: http://dx.doi.org/10.1117/12.2064189 |