Mouse brain imaging using photoacoustic computed tomography

Yang Lou; Jun Xia; Lihong V. Wang

doi:10.1117/12.2039669

3 March 2014 Mouse brain imaging using photoacoustic computed tomography

Yang Lou, Jun Xia, Lihong V. Wang

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 894340 (2014) https://doi.org/10.1117/12.2039669
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Photoacoustic computed tomography (PACT) provides structural and functional information when used in small animal brain imaging. Acoustic distortion caused by bone structures largely limits the deep brain image quality. In our work, we present ex vivo PACT images of freshly excised mouse brain, intending that can serve as a gold standard for future PACT in vivo studies on small animal brain imaging. Our results show that structures such as the striatum, hippocampus, ventricles, and cerebellum can be clearly di erentiated. An artery feature called the Circle of Willis, located at the bottom of the brain, can also be seen. These results indicate that if acoustic distortion can be accurately accounted for, PACT should be able to image the entire mouse brain with rich structural information.

Citation Download Citation

Yang Lou, Jun Xia, and Lihong V. Wang "Mouse brain imaging using photoacoustic computed tomography", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894340 (3 March 2014); https://doi.org/10.1117/12.2039669

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