Simple numerical model of OCT signal evolution due to the diffusion of an optical clearing agent

Natalia A. Trunina; Vladimir L. Derbov; Valery V. Tuchin

doi:10.1117/12.2049685

30 January 2014 Simple numerical model of OCT signal evolution due to the diffusion of an optical clearing agent

Natalia A. Trunina, Vladimir L. Derbov, Valery V. Tuchin

Proceedings Volume 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV; 90310B (2014) https://doi.org/10.1117/12.2049685
Event: Saratov Fall Meeting 2013, 2013, Saratov, Russian Federation

Abstract

A simple numerical model is proposed to describe the process of OCT signal formation in a scattering medium (biological tissue) under the conditions of immersion chemical agent diffusion. Due to optical clearing of the tissue the shape of the OCT A-scan becomes time-dependent, thus providing information about the diffusion rate. The model includes the numerical solution of the diffusion equation, the relation between the concentration of clearing agent and the scattering coefficient, and, finally, the description of the OCT signal formation given the material parameters and with the probe beam geometry taken into account. The test calculations qualitatively reproduce the experimentally observed time behavior of A-scans in samples of human tooth dentine, caused by diffusion of different chemical agents. In particular, it is shown that the non-monotonic A-scans having a maximum can be explained by assuming that the backscattering coefficient giving rise to the OCT signal is, at least partially, subject to optical clearing alongside with the scattering coefficient responsible for the signal attenuation.

Citation Download Citation

Natalia A. Trunina, Vladimir L. Derbov, and Valery V. Tuchin "Simple numerical model of OCT signal evolution due to the diffusion of an optical clearing agent", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310B (30 January 2014); https://doi.org/10.1117/12.2049685

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Diffusion

Scattering

Optical clearing

Laser scattering

Backscatter

Refractive index

Show All Keywords

Keywords/Phrases

Search In:

Publication Years