Olga V. Zlobina,1 Svetlana S. Pakhomy,1 Alla B. Bucharskayahttps://orcid.org/0000-0003-0503-6486,1 Irina O. Bugaeva,1 Galina N. Maslyakova,1 Nikolai G. Khlebtsov,2 Boris N. Khlebtsov,2 Vladimir A. Bogatyrev2
1Saratov State Medical Univ. (Russian Federation) 2Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
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The oral administration of gold nanoparticles at dose 190 mg /kg animal body weight during 8 days leads to changes in
the cellular composition of the mesenteric lymph nodes, the severity and reversibility of the reaction was determined by
the size of gold nanoparticles. The cellular composition of the lymph nodes after the introduction of gold nanoparticle
size of 1-3 nm for 8 days corresponded the control values, indicating the absence of immunotoxicity. Duration of
recovery of cellular composition of the lymph nodes after administration of gold nanoparticles with size 15 nm and 50
nm does not exceed 21 days. It can be concluded that 15 nm and 50 nm nanoparticles have no immunotoxic action at oral
administration.
Olga V. Zlobina,Svetlana S. Pakhomy,Alla B. Bucharskaya,Irina O. Bugaeva,Galina N. Maslyakova,Nikolai G. Khlebtsov,Boris N. Khlebtsov, andVladimir A. Bogatyrev
"The reversibility of morphological changes in the mesenteric lymph nodes after peroral administration of gold nanoparticles", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310P (30 January 2014); https://doi.org/10.1117/12.2048990
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Olga V. Zlobina, Svetlana S. Pakhomy, Alla B. Bucharskaya, Irina O. Bugaeva, Galina N. Maslyakova, Nikolai G. Khlebtsov, Boris N. Khlebtsov, Vladimir A. Bogatyrev, "The reversibility of morphological changes in the mesenteric lymph nodes after peroral administration of gold nanoparticles," Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310P (30 January 2014); https://doi.org/10.1117/12.2048990