Synthesis of biocompatible SiO2 coated ZnO quantum dots for cell imaging

Min Zhang; Qian Wang; Haiyan Chen; Yueqing Gu

doi:10.1117/12.2068696

17 September 2014 Synthesis of biocompatible SiO₂ coated ZnO quantum dots for cell imaging

Min Zhang, Qian Wang, Haiyan Chen, Yueqing Gu

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92300B (2014) https://doi.org/10.1117/12.2068696
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Quantum dots (QDs) is a promising candidate for biomedical imaging. However, the bio-toxicity of traditional quantum dots obstructed their further application seriously. In this work, a simple solution growth method was utilized to synthesize ZnO QDs. However, their self-assemble feature makes them unstable in aqueous solution. Furthermore, (3-Aminopropyl) triethoxysilane was selected as a capping agent to stabilize ZnO QDs and then ZnO@SiO₂ nanoparticles were obtained. They dispersed excellently in water and exhibited favorable fluorescence properties owing to the protection of silane. The biocompatability of ZnO@SiO₂ nanoparticles was verified by MTT assy. The cell affinity studies demonstrated that ZnO@SiO₂ nanoparticles could be uptaken by cells efficiently. Therefore, the as-prepared ZnO@SiO₂ nanoparticles is a promising candidate for applications in cell imaging.

Citation Download Citation

Min Zhang, Qian Wang, Haiyan Chen, and Yueqing Gu "Synthesis of biocompatible SiO₂ coated ZnO quantum dots for cell imaging", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92300B (17 September 2014); https://doi.org/10.1117/12.2068696

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