Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivative for bacterial skin infection

Zhuo Chen; Yaxin Zhang; Linsen Li; Shanyong Zhou; Jincan Chen; Ping Hu; Mingdong Huang

doi:10.1117/12.2068160

17 September 2014 Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivative for bacterial skin infection

Zhuo Chen, Yaxin Zhang, Linsen Li, Shanyong Zhou, Jincan Chen, Ping Hu, Mingdong Huang

Author Affiliations +

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923017 (2014) https://doi.org/10.1117/12.2068160
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Folliculitis, furunculosis and acne vulgaris are very common skin disorders of the hair follicles and are associated with large grease-producing (sebaceous) glands. Although the detailed mechanisms involved these skin disorders are not fully understood, it is believed that the bacteria Propionibacterium acnes and Staphylococcus aureus are the key pathogenic factors involved. Conventional treatments targeting the pathogenic factors include a variety of topical and oral medications such as antibiotics. The wide use of antibiotics leads to bacterial resistance, and hence there is a need for new alternatives in above bacterial skin treatment. Photodynamic antimicrobial chemotherapy (PACT) is based on an initial photosensitization of the infected area, followed by irradiation with visible light, producing singlet oxygen which is cytotoxic to bacteria. Herein we reported a zinc phthalocyanine derivative, pentalysine β-carbonylphthalocyanine zinc (ZnPc-(Lys)₅) and its PACT effect for the bacteria involved in these skin infections. Our results demonstrated strong bactericidal effects of this photosensitizer on both strains of the bacteria, suggesting ZnPc-(Lys)₅ as a promising antimicrobial photosensitizer for the treatment of infectious diseases caused by these bacteria.

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Zhuo Chen, Yaxin Zhang, Linsen Li, Shanyong Zhou, Jincan Chen, Ping Hu, and Mingdong Huang "Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivative for bacterial skin infection", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923017 (17 September 2014); https://doi.org/10.1117/12.2068160

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KEYWORDS

Bacteria

Skin

Zinc

Photoacoustic tomography

Photodynamic therapy

Oxygen

Pathogens

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