Label-free visualization of collagen in submucosa as a potential diagnostic marker for early detection of colorectal cancer

Jingting Qiu; Yinghong Yang; Weizhong Jiang; Changyin Feng; Zhifen Chen; Guoxian Guan; Xiaoqin Zhu; Shuangmu Zhuo; Jianxin Chen

doi:10.1117/12.2068498

17 September 2014 Label-free visualization of collagen in submucosa as a potential diagnostic marker for early detection of colorectal cancer

Jingting Qiu, Yinghong Yang, Weizhong Jiang, Changyin Feng, Zhifen Chen, Guoxian Guan, Xiaoqin Zhu, Shuangmu Zhuo, Jianxin Chen

Author Affiliations +

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92301M (2014) https://doi.org/10.1117/12.2068498
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

The collagen signature in colorectal submucosa is changed due to remodeling of the extracellular matrix during the malignant process and plays an important role in noninvasive early detection of human colorectal cancer. In this work, multiphoton microscopy (MPM) was used to monitor the changes of collagen in normal colorectal submucosa (NCS) and cancerous colorectal submucosa (CCS). What’s more, the collagen content was quantitatively measured. It was found that in CCS the morphology of collagen becomes much looser and the collagen content is significantly reduced compared to NCS. These results suggest that MPM has the ability to provide collagen signature as a potential diagnostic marker for early detection of colorectal cancer.

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Jingting Qiu, Yinghong Yang, Weizhong Jiang, Changyin Feng, Zhifen Chen, Guoxian Guan, Xiaoqin Zhu, Shuangmu Zhuo, and Jianxin Chen "Label-free visualization of collagen in submucosa as a potential diagnostic marker for early detection of colorectal cancer", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301M (17 September 2014); https://doi.org/10.1117/12.2068498

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