Photoacoustic signal simulation and detection optimization based on laser-scanning optical-resolution photoacoustic microscopy

Lin Li; Yi Du; Qingliang Zhao; Qian Li; Xinyu Chai; Chuanqing Zhou

doi:10.1117/12.2073627

20 November 2014 Photoacoustic signal simulation and detection optimization based on laser-scanning optical-resolution photoacoustic microscopy

Lin Li, Yi Du, Qingliang Zhao, Qian Li, Xinyu Chai, Chuanqing Zhou

Author Affiliations +

Proceedings Volume 9268, Optics in Health Care and Biomedical Optics VI; 92682R (2014) https://doi.org/10.1117/12.2073627
Event: SPIE/COS Photonics Asia, 2014, Beijing, China

Abstract

Laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) has a high application potential in ophthalmology and other clinical fields because of its high resolution and imaging speed. The stationary unfocused ultrasonic transducer of this system decides the efficiency and field of view (FOV) of photoacoustic signal detection, but the refraction and attenuation of laser generated photoacoustic signal in different tissue mediums will cause signal strength and direction distribution uneven. In this study, we simulated the photoacoustic signal propagation and detection in compound medium models with different tissue parameters using k-space method based on LSOR-PAM imaging principle. The results show a distance related signal strength attenuation and FOV changes related to transducer angle. Our study provides a method for photoacoustic signal detection optimization for different complex tissue structure with LSOR-PAM.

Citation Download Citation

Lin Li, Yi Du, Qingliang Zhao, Qian Li, Xinyu Chai, and Chuanqing Zhou "Photoacoustic signal simulation and detection optimization based on laser-scanning optical-resolution photoacoustic microscopy", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92682R (20 November 2014); https://doi.org/10.1117/12.2073627

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