Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

Christine M. O'Brien; Elizabeth Vargis; Chris Slaughter; Amy P Rudin; Jennifer L. Herington; Kelly A. Bennett; Jeff Reese; Anita Mahadevan-Jansen

doi:10.1117/12.2077775

9 March 2015 Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

Christine M. O'Brien, Elizabeth Vargis, Chris Slaughter, Amy P Rudin, Jennifer L. Herington, Kelly A. Bennett, Jeff Reese, Anita Mahadevan-Jansen

Author Affiliations +

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93032F (2015) https://doi.org/10.1117/12.2077775
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.

Citation Download Citation

Christine M. O'Brien, Elizabeth Vargis, Chris Slaughter, Amy P Rudin, Jennifer L. Herington, Kelly A. Bennett, Jeff Reese, and Anita Mahadevan-Jansen "Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032F (9 March 2015); https://doi.org/10.1117/12.2077775

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