Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance

Pablo A. Valdes; Joseph Angelo; Sylvain Gioux

doi:10.1117/12.2085051

10 March 2015 Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance

Pablo A. Valdes, Joseph Angelo, Sylvain Gioux

Author Affiliations +

Proceedings Volume 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II; 93050J (2015) https://doi.org/10.1117/12.2085051
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Fluorescence imaging has shown promise as an adjunct to improve the extent of resection in neurosurgery and oncologic surgery. Nevertheless, current fluorescence imaging techniques do not account for the heterogeneous attenuation effects of tissue optical properties. In this work, we present a novel imaging system that performs real time quantitative fluorescence imaging using Single Snapshot Optical Properties (SSOP) imaging. We developed the technique and performed initial phantom studies to validate the quantitative capabilities of the system for intraoperative feasibility. Overall, this work introduces a novel real-time quantitative fluorescence imaging method capable of being used intraoperatively for neurosurgical guidance.

Citation Download Citation

Pablo A. Valdes, Joseph Angelo, and Sylvain Gioux "Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance", Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 93050J (10 March 2015); https://doi.org/10.1117/12.2085051

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