En-face imaging of the ellipsoid zone in the retina from optical coherence tomography B-scans

T. Holmes; S. Larkin; M. Downing; K. Csaky

doi:10.1117/12.2074193

20 March 2015 En-face imaging of the ellipsoid zone in the retina from optical coherence tomography B-scans

T. Holmes, S. Larkin, M. Downing, K. Csaky

Proceedings Volume 9307, Ophthalmic Technologies XXV; 93071O (2015) https://doi.org/10.1117/12.2074193
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

It is generally believed that photoreceptor integrity is related to the ellipsoid zone appearance in optical coherence tomography (OCT) B-scans. Algorithms and software were developed for viewing and analyzing the ellipsoid zone. The software performs the following: (a), automated ellipsoid zone isolation in the B-scans, (b), en-face view of the ellipsoid-zone reflectance, (c), alignment and overlay of (b) onto reflectance images of the retina, and (d), alignment and overlay of (c) with microperimetry sensitivity points. Dataset groups were compared from normal and dry age related macular degeneration (DAMD) subjects. Scalar measurements for correlation against condition included the mean and standard deviation of the ellipsoid zone’s reflectance. The imageprocessing techniques for automatically finding the ellipsoid zone are based upon a calculation of optical flow which tracks the edges of laminated structures across an image. Statistical significance was shown in T-tests of these measurements with the population pools separated as normal and DAMD subjects. A display of en-face ellipsoid-zone reflectance shows a clear and recognizable difference between any of the normal and DAMD subjects in that they show generally uniform and nonuniform reflectance, respectively, over the region near the macula. Regions surrounding points of low microperimetry (μP) sensitivity have nonregular and lower levels of ellipsoid-zone reflectance nearby. These findings support the idea that the photoreceptor integrity could be affecting both the ellipsoid-zone reflectance and the sensitivity measurements.

Citation Download Citation

T. Holmes, S. Larkin, M. Downing, and K. Csaky "En-face imaging of the ellipsoid zone in the retina from optical coherence tomography B-scans", Proc. SPIE 9307, Ophthalmic Technologies XXV, 93071O (20 March 2015); https://doi.org/10.1117/12.2074193

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Reflectivity

Optical coherence tomography

Retina

Optical flow

Algorithm development

Eye

Scanning laser ophthalmoscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years