Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

Chih-Hao Liu; Manmohan Singh; Jiasong Li; Zhaolong Han; Chen Wu; Shang Wang; Rita Idugboe; Raksha Raghunathan; Valery P. Zakharov; Emil  N. Sobol; Valery V. Tuchin; Michael Twa; Kirill V. Larin

doi:10.1117/12.2079854

5 March 2015 Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

Chih-Hao Liu, Manmohan Singh, Jiasong Li, Zhaolong Han, Chen Wu, Shang Wang, Rita Idugboe, Raksha Raghunathan, Valery P. Zakharov, Emil N. Sobol, Valery V. Tuchin, Michael Twa, Kirill V. Larin

Author Affiliations +

Proceedings Volume 9322, Dynamics and Fluctuations in Biomedical Photonics XII; 93220B (2015) https://doi.org/10.1117/12.2079854
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We report the first study on using optical coherence elastography (OCE) to quantitatively monitor the elasticity change of the hyaline cartilage during the optical clearing administrated by glucose solution. The measurement of the elasticity is verified using uniaxial compression test, demonstrating the feasibility of using OCE to quantify the Young’s modulus of the cartilage tissue. As the results, we found that the stiffness of the hyaline cartilage increases during the optical clearing of the tissue. This study might be potentially useful for the early detection of osteoarthritis disease.

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Chih-Hao Liu, Manmohan Singh, Jiasong Li, Zhaolong Han, Chen Wu, Shang Wang, Rita Idugboe, Raksha Raghunathan, Valery P. Zakharov, Emil N. Sobol, Valery V. Tuchin, Michael Twa, and Kirill V. Larin "Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography", Proc. SPIE 9322, Dynamics and Fluctuations in Biomedical Photonics XII, 93220B (5 March 2015); https://doi.org/10.1117/12.2079854

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