Correlation mapping microscopy

James McGrath; Sergey Alexandrov; Peter Owens; Hrebesh M. Subhash; Martin J. Leahy

doi:10.1117/12.2077988

5 March 2015 Correlation mapping microscopy

James McGrath, Sergey Alexandrov, Peter Owens, Hrebesh M. Subhash, Martin J. Leahy

Proceedings Volume 9322, Dynamics and Fluctuations in Biomedical Photonics XII; 93220L (2015) https://doi.org/10.1117/12.2077988
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Changes in the microcirculation are associated with conditions such as Raynauds disease. Current modalities used to assess the microcirculation such as nailfold capillaroscopy are limited due to their depth ambiguity. A correlation mapping technique was recently developed to extend the capabilities of Optical Coherence Tomography to generate depth resolved images of the microcirculation. Here we present the extension of this technique to microscopy modalities, including confocal microscopy. It is shown that this correlation mapping microscopy technique can extend the capabilities of conventional microscopy to enable mapping of vascular networks in vivo with high spatial resolution.

Citation Download Citation

James McGrath, Sergey Alexandrov, Peter Owens, Hrebesh M. Subhash, and Martin J. Leahy "Correlation mapping microscopy", Proc. SPIE 9322, Dynamics and Fluctuations in Biomedical Photonics XII, 93220L (5 March 2015); https://doi.org/10.1117/12.2077988

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