Quantifying bone thickness, light transmission, and  contrast interrelationships in transcranial  photoacoustic imaging

Muyinatu A. Lediju Bell; Anastasia K. Ostrowski; Ke Li; Peter Kaanzides; Emad Boctor

doi:10.1117/12.2078613

11 March 2015 Quantifying bone thickness, light transmission, and contrast interrelationships in transcranial photoacoustic imaging

Muyinatu A. Lediju Bell, Anastasia K. Ostrowski, Ke Li, Peter Kaanzides, Emad Boctor

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93230C (2015) https://doi.org/10.1117/12.2078613
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We previously introduced photoacoustic imaging to detect blood vessels surrounded by bone and thereby eliminate the deadly risk of carotid artery injury during endonasal, transsphenoidal surgeries. Light would be transmitted through an optical fiber attached to the surgical drill, while a transcranial probe placed on the temporal region of the skull receives photoacoustic signals. This work quantifies changes in photoacoustic image contrast as the sphenoid bone is drilled. Frontal bone from a human adult cadaver skull was cut into seven 3 cm x 3 cm chips and sanded to thicknesses ranging 1-4 mm. For 700-940 nm wavelengths, the average optical transmission through these specimens increased from 19% to 44% as bone thickness decreased, with measurements agreeing with Monte Carlo simulations within 5%. These skull specimens were individually placed in the optical pathway of a 3.5 mm diameter, cylindrical, vessel-mimicking photoacoustic target, as the laser wavelength was varied between 700-940 nm. The mean optical insertion loss and photoacoustic image contrast loss due to the bone specimens were 56-80% and 46-79%, respectively, with the majority of change observed when the bone was ≤2 mm thick. The decrease in contrast is directly proportional to insertion loss over this thickness range by factors of 0.8-1.1 when multiple wavelengths are considered. Results suggest that this proportional relationship may be used to determine the amount of bone that remains to be drilled when the thickness is 2 mm or less.

Citation Download Citation

Muyinatu A. Lediju Bell, Anastasia K. Ostrowski, Ke Li, Peter Kaanzides, and Emad Boctor "Quantifying bone thickness, light transmission, and contrast interrelationships in transcranial photoacoustic imaging", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93230C (11 March 2015); https://doi.org/10.1117/12.2078613

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