In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography

Li Lin; Jun Xia; Terence T. W. Wong; Ruiying Zhang; Lihong V. Wang

doi:10.1117/12.2076482

11 March 2015 In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography

Li Lin, Jun Xia, Terence T. W. Wong, Ruiying Zhang, Lihong V. Wang

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93230G (2015) https://doi.org/10.1117/12.2076482
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We demonstrate, by means of internal light delivery, photoacoustic imaging of the deep brain of rats in vivo. With fiber illumination via the oral cavity, we delivered light directly into the bottom of the brain, much more than can be delivered by external illumination. The study was performed using a photoacoustic computed tomography (PACT) system equipped with a 512-element full-ring transducer array, providing a full two-dimensional view aperture. Using internal illumination, the PACT system provided clear cross sectional photoacoustic images from the palate to the middle brain of live rats, revealing deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.

Citation Download Citation

Li Lin, Jun Xia, Terence T. W. Wong, Ruiying Zhang, and Lihong V. Wang "In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93230G (11 March 2015); https://doi.org/10.1117/12.2076482

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available