Universal temperature-dependent normalized optoacoustic response of blood

Elena V. Petrova; Anton Liopo; Alexander A. Oraevsky; Sergey A. Ermilov

doi:10.1117/12.2083594

11 March 2015 Universal temperature-dependent normalized optoacoustic response of blood

Elena V. Petrova, Anton Liopo, Alexander A. Oraevsky, Sergey A. Ermilov

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93231Y (2015) https://doi.org/10.1117/12.2083594
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We found and interpreted the universal temperature-dependent optoacoustic (photoacoustic) response (ThOR) in blood; the normalized ThOR is invariant with respect to hematocrit at the hemoglobin’s isosbestic point. The unique compartmentalization of hemoglobin, the primary optical absorber at 805 nm, inside red blood cells (RBCs) explains the effect. We studied the temperature dependence of Gruneisen parameter in blood and aqueous solutions of hemoglobin and for the first time experimentally observed transition through the zero optoacoustic response at temperature T₀, which was proved to be consistent for various blood samples. On the other hand, the hemoglobin solutions demonstrated linear concentration function of the temperature T₀. When this function was extrapolated to the average hemoglobin concentration inside erythrocytes, the temperature T₀ was found equivalent to that measured in whole and diluted blood. The obtained universal curve of blood ThOR was validated in both transparent and light scattering media. The discovered universal optoacoustic temperature dependent blood response provides foundation for future development of non-invasive in vivo temperature monitoring in vascularized tissues and blood vessels.

Citation Download Citation

Elena V. Petrova, Anton Liopo, Alexander A. Oraevsky, and Sergey A. Ermilov "Universal temperature-dependent normalized optoacoustic response of blood", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231Y (11 March 2015); https://doi.org/10.1117/12.2083594

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