Noninvasive 3D elasticity mapping using phase-stabilized optical coherence elastography

Manmohan Singh; Jiasong Li; Shang Wang; Michael Twa; Kirill V. Larin

doi:10.1117/12.2078315

6 March 2015 Noninvasive 3D elasticity mapping using phase-stabilized optical coherence elastography

Manmohan Singh, Jiasong Li, Shang Wang, Michael Twa, Kirill V. Larin

Proceedings Volume 9327, Optical Elastography and Tissue Biomechanics II; 932703 (2015) https://doi.org/10.1117/12.2078315
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We demonstrate a novel method for noninvasive elasticity mapping in three dimensions using phase stabilized swept source optical coherence elastography (PhS-SSOCE). By calculating the velocity in all radial directions from the origin of the induced shear wave, a volumetric elasticity map of the sample was generated. Due to the submicrometer spatial sensitivity of PhS-SSOCE, the loading force and the induced deformation amplitude can be minimal, thus preserving the structure and function of delicate tissues such as the cornea and sclera of the eye. Tissue mimicking agar phantoms were utilized for proof of concept testing and the results show that this method can noninvasively provide a three dimensional estimation of sample elasticity.

Citation Download Citation

Manmohan Singh, Jiasong Li, Shang Wang, Michael Twa, and Kirill V. Larin "Noninvasive 3D elasticity mapping using phase-stabilized optical coherence elastography", Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 932703 (6 March 2015); https://doi.org/10.1117/12.2078315

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